Challenging the Wisdom of Nrf2 as a Target for Drug Development

A little regulatory protein called NF-E2 related nuclear transcription factor, commonly abbreviated Nrf2, interacts with DNA upstream of many cellular defense genes, in conjunction with other proteins, to control toxins that contribute to oxidative stress. Since oxidative stress, a condition characterized by overabundance of free radicals, is associated with aging, inflammation, exposure to environmental toxins, and almost every disease known ...

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Water and Organic Matter Make Gardens Productive in Desert Soils

Gardening in the desert presents challenges that are rarely addressed by gardening experts who honed their skills in more humid climates.   Here in the Southwest, it is not uncommon to see precipitation values for the entire year that equal rainfall received in a single storm in more humid climates. When annual precipitation falls below 15 inches, soil, which can ...

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Ending the Fight with Diversification

Soil, water, and air pollution. Chronic disease epidemics (Heart Disease, Obesity, Diabetes….) Chemical dependencies Civil unrest Food insecurity…. Wouldn’t it be wonderful if one set of simple and affordable actions could address all of these problems simultaneously? End-O-Fite Enterprises LLC was built on the premise that the most significant common denominator among all these problems is the uniformly regulated management ...

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Sowing the Seeds of Victory

Home gardening is vital to the security of any nation During the first and second World Wars, victory gardens were popular in countries on both sides of the fighting.   The ability to produce food close to home was considered a vital component of national security, and was recognized as crucial to the war effort.  This first half of the ...

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Don’t Throw the Baby with the Bathwater: Hemp as a Cash Crop.

As a girl in the 1970’s, all I knew about “hemp” was that it was quite popular with a group of people I was uncomfortable around.  We called it “marijuana.”  I remember being advised by my teenaged relatives to smoke marijuana because, by their wisdom, if I could not smoke a joint properly when I got to Junior High, people ...

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The Trojan Horse of Mandatory Public Education

In the late 19th century, Americans from all walks of life recognized the value of a good education as the foundation of a free society.  It seemed self evident that basic skills like reading, writing, and math were skills that separated the rich from the poor.  Access to education promised a key to upward mobility.  So when mandatory public education ...

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Fixing Our Food Systems

What is a food system? Food systems, at the most basic level, include the spectrum of interactions between humanity and the environment we live in.  Healthy food systems are economically and nutritionally secure food systems.  They ensure access to safe, healthy, and nutritious food for all people, and they serve as the foundation to the remaining economy.   When food ...

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Fungi and the Circle of Life

Why Fungi Represent the Circle of Life People look at me funny when I say that fungi are the circle of life.  Comments range from the disinterested, “Yeah, right.   Whatever,” to the challenging “What are you talking about?” Well, here is what I am talking about. Fungi, particularly microfungi, the kind you need a microscope to see, are critical to ...

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Is Food Really the Best Medicine?

  I typically cite food as the best medicine.  To keep the regulators happy, I will define “medicine” herein as “stuff that makes people healthy so they feel better.” I don’t want to be accused of trying to diagnose, prevent, treat, or cure diseases that are tied to legal definitions I know little about. But getting back to my point, ...

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Hacking Common Sense to put Medical Data in the Cloud

In the March 24, 2014 edition of Time Magazine, Yves Béhar describes “LifeTiles,” fasionable sensors that would non-invasively monitor a person’s health.  LifeTiles would share data with cloud algorithms to provide individualized feedback that would presumably help the user make better health choices. Since the technology to do this exists, it is conceivable that such a device could soon be ...

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